Assembly, remodelled

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Assembly, remodelled

Biochemical assays reveal that nucleosome maturation and chromatin remodelling by the motor protein Chd1 are distinct, separable enzymatic activities.

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Proteases are the largest family of enzymes in the human genome and play central roles in a wide range of physiological processes.1 To carry out these diverse functions, proteolytic enzymes have evolved highly tuned substrate specificities that allow them to degrade specific cellular proteins in response to appropriate signals. For many proteases, this specificity is encoded by the amino acid s...

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ژورنال

عنوان ژورنال: eLife

سال: 2013

ISSN: 2050-084X

DOI: 10.7554/elife.01270